The genetic mutations underlying treatment resistance in non-small cell lung cancer (NSCLC) are more complex and dynamic than previously thought. Analysis of 355 biopsied tumors from patients who ...

A new study headed by teams at the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI), and Open Targets has indicated how mutations that cause cancer drug resistance fall ...

Researchers published a new study, “Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution,” in Cell that they say solves the mystery of what drives the genomic ...

Researchers at Cardiff University have uncovered how a particularly severe form of DNA damage arises—shedding new light on ...

Researchers have developed a new technology called tARC-seq that revealed a genetic mechanism affecting SARS-CoV-2 divergence and enabled the team to calculate SARS-CoV-2's mutation rate. Using ...

BTK and PLCG2 mutations are prevalent in patients with CLL treated with BTKi, but other resistance mechanisms may exist. BTK/PLCG2 mutational profiles have not yet proven useful in guiding subsequent ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

Progressing lesions of 25 patients with GISTs refractory to ripretinib were sequenced for KIT resistance mutations. Resistant genotypes were validated and characterized using novel cell line models ...

Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a ...

Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors, according to a new study from Duke University. The findings, published in PLOS Biology, ...