Complement is a subsystem of immunity that's fast acting and disregulated in multiple inflammatory diseases. Inhibition of complement is a young niche that's gonna get lots more attention soon.

When drug development and the immune system collide we get CAR-T, checkpoint inhibitors, oncolytic vaccines, monoclonal antibodies and more. These fields have produced many therapies and garnered a ...

Iptacopan is an innovative, first-in-class oral small molecule that reversibly inhibits factor B—a crucial serine protease in the alternative pathway of the complement system. By targeting this point ...